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A new class of generalized log rank tests for interval-censored failure time data

机译:针对间隔检查的故障时间数据的一类新的广义日志等级测试

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摘要

This paper discusses nonparametric comparison of survival functions when one observes only interval-censored failure time data (Peto and Peto, 1972; Sun, 2006; Zhao et al.; 2008). For the problem, a few procedures have been proposed in the literature. However, most of the existing test procedures determine the test results or p-values based on ad hoc methods or the permutation approach. Furthermore for the test procedures whose asymptotic distributions have been derived, the results are only for the null hypothesis. In other words, no nonparametric test procedure exists that has a known asymptotic distribution under the alternative hypothesis and thus can be employed to carry out the power and test size calculation. In this paper, a new class of generalized log-rank tests is proposed and their asymptotic distributions are derived under both null and alternative hypotheses. A simulation study is conducted to assess their performance for finite sample situations and an illustrative example is provided.
机译:本文讨论了仅观察间隔检查的失效时间数据时生存函数的非参数比较(Peto和Peto,1972; Sun,2006; Zhao等,2008)。对于该问题,文献中已经提出了一些程序。但是,大多数现有的测试过程都基于临时方法或置换方法来确定测试结果或p值。此外,对于已得出渐近分布的测试程序,结果仅适用于原假设。换句话说,不存在在替代假设下具有已知渐近分布的非参数测试程序,因此可以用来执行功效和测试大小的计算。本文提出了一类新的广义对数秩检验,并在零假设和替代假设下导出了它们的渐近分布。进行了仿真研究,以评估其在有限样本情况下的性能,并提供了一个说明性示例。

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